InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Suclg1

Summary

InnateDB Gene

IDBG-158207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suclg1

Gene Name

succinate-CoA ligase, GDP-forming, alpha subunit

Synonyms

1500000I01Rik; Sucla1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052738

Encoded Proteins

IDBP-158209

succinate-CoA ligase, GDP-forming, alpha subunit

IDBP-620024

succinate-CoA ligase, GDP-forming, alpha subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163541:
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:73248382-73276911

Strand

Forward strand

Band

Transcripts

ENSMUST00000064740	ENSMUSP00000065113
ENSMUST00000123159	ENSMUSP00000134171
ENSMUST00000127660
ENSMUST00000173366
ENSMUST00000173409

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0004776	succinate-CoA ligase (GDP-forming) activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0048037	cofactor binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006104	succinyl-CoA metabolic process
GO:0006105	succinate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0045244	succinate-CoA ligase complex (GDP-forming)
GO:0070062	extracellular vesicular exosome