InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mlh3

Summary

InnateDB Protein

IDBP-158239.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Mlh3

Protein Name

mutL homolog 3 (E coli)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019378

InnateDB Gene

IDBG-158237 (Mlh3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0019237	centromeric DNA binding
GO:0030983	mismatched DNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006298	mismatch repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007130	synaptonemal complex assembly
GO:0007131	reciprocal meiotic recombination
GO:0007140	male meiosis
GO:0007144	female meiosis I
GO:0008104	protein localization

Cellular Component

GO:0000793	condensed chromosome
GO:0000795	synaptonemal complex
GO:0001673	male germ cell nucleus
GO:0005654	nucleoplasm
GO:0005712	chiasma
GO:0032300	mismatch repair complex

Protein Structure and Domains

PDB ID

MGI:1353455

InterPro

IPR001202 WW domain
IPR003594 Histidine kinase-like ATPase, ATP-binding domain
IPR013507 DNA mismatch repair protein, C-terminal
IPR014790 MutL, C-terminal, dimerisation
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF00397
PF02518
PF13581
PF01119
PF08676

PRINTS

PIRSF

SMART

SM00456
SM00387
SM00853

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite