InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc28a3

Summary

InnateDB Protein

IDBP-158369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc28a3

Protein Name

solute carrier family 28 (sodium-coupled nucleoside transporter), member 3

Synonyms

Cnt3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022036

InnateDB Gene

IDBG-158367 (Slc28a3)

Protein Structure

UniProt Annotation

Function

Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001882	nucleoside binding
GO:0005415	nucleoside:sodium symporter activity
GO:0015389	pyrimidine- and adenine-specific:sodium symporter activity
GO:0015390	purine-specific nucleoside:sodium symporter activity

Biological Process

GO:0006810	transport
GO:0006863	purine nucleobase transport
GO:0015855	pyrimidine nucleobase transport
GO:0015860	purine nucleoside transmembrane transport
GO:0015864	pyrimidine nucleoside transport
GO:0072531	pyrimidine-containing compound transmembrane transport

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2137361

InterPro

IPR002668 Na dependent nucleoside transporter
IPR011642 Nucleoside recognition Gate
IPR011657 Na dependent nucleoside transporter, C-terminal
IPR018270 Concentrative nucleoside transporter, metazoan/bacterial

PFAM

PF01773
PF07670
PF07662

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ERH8

PhosphoSite