InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Axl

Summary

InnateDB Protein

IDBP-158472.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Axl

Protein Name

AXL receptor tyrosine kinase

Synonyms

AI323647; Ark; Tyro7; Ufo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083110

InnateDB Gene

IDBG-158468 (Axl)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001764	neuron migration
GO:0001779	natural killer cell differentiation
GO:0001974	blood vessel remodeling
GO:0006468	protein phosphorylation
GO:0006909	phagocytosis
GO:0006954	inflammatory response
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0007283	spermatogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021885	forebrain cell migration
GO:0030168	platelet activation
GO:0031668	cellular response to extracellular stimulus
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032940	secretion by cell
GO:0034101	erythrocyte homeostasis
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042698	ovulation cycle
GO:0043066	negative regulation of apoptotic process
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0051250	negative regulation of lymphocyte activation
GO:0060068	vagina development

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1347244

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM