Version 5.4
Mus musculus Gene: Axl
Summary
InnateDB Gene IDBG-158468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Axl
Gene Name AXL receptor tyrosine kinase
Synonyms AI323647; Ark; Tyro7; Ufo
Species Mus musculus
Ensembl Gene ENSMUSG00000002602
Encoded Proteins
IDBP-158470
AXL receptor tyrosine kinase
IDBP-158472
AXL receptor tyrosine kinase
IDBP-531890
AXL receptor tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23954153
Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.
InnateDB Annotation from Orthologs
Summary
PMID 18083102
[Homo sapiens] AXL is a pleiotropic inhibitor of the innate immune response in dendritic cells, this tyrosine protein kinase is induced by IFNAR/STAT1 signalling and TLR ligation predominantly through TLR activation of the feed-forward cytokine pathway
PMID 19657094
[Homo sapiens] AXL regulates survival and migration of human dendritic cells by an IFN-alpha-inducible AXL/GAS6 pathway.
PMID 23071254
[Homo sapiens] TGF-β1-induced AXL enhances apoptotic cell uptake and blocks proinflammatory cytokine production in the skin.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167601:
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:25757273-25788705
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000002677 ENSMUSP00000002677
ENSMUST00000085948 ENSMUSP00000083110
ENSMUST00000124442
ENSMUST00000137211
ENSMUST00000132989
ENSMUST00000132038 ENSMUSP00000114907
ENSMUST00000147680
ENSMUST00000137383
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032036 myosin heavy chain binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001764 neuron migration
GO:0001779 natural killer cell differentiation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0001974 blood vessel remodeling
GO:0006468 protein phosphorylation
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007283 spermatogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021885 forebrain cell migration
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0031100 organ regeneration
GO:0031668 cellular response to extracellular stimulus
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032940 secretion by cell
GO:0034101 erythrocyte homeostasis
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035457 cellular response to interferon-alpha
GO:0042698 ovulation cycle
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048469 cell maturation
GO:0051250 negative regulation of lymphocyte activation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060068 vagina development
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0097028 dendritic cell differentiation
GO:2000669 negative regulation of dendritic cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000167601
View Gene Order
ENSBTAG00000003166
Not yet available
Pathways
NETPATH
REACTOME
REACT_227951
Signaling by VEGF pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
KEGG
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4128
RefSeq NM_001190974 NM_001190975 NM_009465 XM_006539989 XM_006539990 XM_006539991
OMIM
CCDS CCDS20996 CCDS57528
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca