InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bmpr2

Summary

InnateDB Protein

IDBP-158576.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmpr2

Protein Name

bone morphogenic protein receptor, type II (serine/threonine kinase)

Synonyms

2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPRII; BRK-3; Gm20272;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084701

InnateDB Gene

IDBG-158574 (Bmpr2)

Protein Structure

UniProt Annotation

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001707	mesoderm formation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0002063	chondrocyte development
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420	brain development
GO:0009267	cellular response to starvation
GO:0009952	anterior/posterior pattern specification
GO:0010595	positive regulation of endothelial cell migration
GO:0010634	positive regulation of epithelial cell migration
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916	regulation of lung blood pressure
GO:0023014	signal transduction by phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045906	negative regulation of vasoconstriction
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048286	lung alveolus development
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0060041	retina development in camera-type eye
GO:0060173	limb development
GO:0060836	lymphatic endothelial cell differentiation
GO:0060840	artery development
GO:0060841	venous blood vessel development
GO:0061298	retina vasculature development in camera-type eye
GO:1902731	negative regulation of chondrocyte proliferation
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:1095407

InterPro

IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF01064
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt