InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bmpr2

Summary

InnateDB Gene

IDBG-158574.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bmpr2

Gene Name

bone morphogenetic protein receptor, type II (serine/threonine kinase)

Synonyms

2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPRII; BRK-3; Gm20272

Species

Mus musculus

Ensembl Gene

ENSMUSG00000067336

Encoded Proteins

IDBP-158576

bone morphogenic protein receptor, type II (serine/threonine kinase)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:59763400-59879014

Strand

Forward strand

Band

Transcripts

ENSMUST00000087435	ENSMUSP00000084701
ENSMUST00000190659
ENSMUST00000186246

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001707	mesoderm formation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001946	lymphangiogenesis
GO:0001974	blood vessel remodeling
GO:0002063	chondrocyte development
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007420	brain development
GO:0009267	cellular response to starvation
GO:0009952	anterior/posterior pattern specification
GO:0010595	positive regulation of endothelial cell migration
GO:0010634	positive regulation of epithelial cell migration
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916	regulation of lung blood pressure
GO:0023014	signal transduction by phosphorylation
GO:0030308	negative regulation of cell growth
GO:0030501	positive regulation of bone mineralization
GO:0030509	BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0042127	regulation of cell proliferation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045906	negative regulation of vasoconstriction
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048286	lung alveolus development
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0060041	retina development in camera-type eye
GO:0060173	limb development
GO:0060836	lymphatic endothelial cell differentiation
GO:0060840	artery development
GO:0060841	venous blood vessel development
GO:0061298	retina vasculature development in camera-type eye
GO:1902731	negative regulation of chondrocyte proliferation
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body