InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm4c

Summary

InnateDB Protein

IDBP-158614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm4c

Protein Name

lysine (K)-specific demethylase 4C

Synonyms

2410141F18Rik; AA517467; Gasc1; Jmjd2c;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077017

InnateDB Gene

IDBG-158612 (Kdm4c)

Protein Structure

UniProt Annotation

Function

Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00537}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0050681	androgen receptor binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0033169	histone H3-K9 demethylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000790

nuclear chromatin

Protein Structure and Domains

PDB ID

MGI:1924054

InterPro

IPR001965 Zinc finger, PHD-type
IPR002999 Tudor domain
IPR003347 JmjC domain
IPR003349 Transcription factor jumonji, JmjN
IPR011011 Zinc finger, FYVE/PHD-type

PFAM

PF00567
PF02373
PF08007
PF02375

PRINTS

PIRSF

SMART

SM00249
SM00333
SM00558
SM00545

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VCD7