InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kdm4c

Summary

InnateDB Gene

IDBG-158612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kdm4c

Gene Name

lysine (K)-specific demethylase 4C

Synonyms

2410141F18Rik; AA517467; Gasc1; Jmjd2c

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028397

Encoded Proteins

IDBP-158614

lysine (K)-specific demethylase 4C

IDBP-158618

lysine (K)-specific demethylase 4C

IDBP-538487

lysine (K)-specific demethylase 4C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107077:
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:74242497-74405860

Strand

Forward strand

Band

Transcripts

ENSMUST00000077851	ENSMUSP00000077017
ENSMUST00000030102	ENSMUSP00000030102
ENSMUST00000156065
ENSMUST00000149295	ENSMUSP00000118728
ENSMUST00000150439
ENSMUST00000148753

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0050681	androgen receptor binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0033169	histone H3-K9 demethylation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000790

nuclear chromatin

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107077

View Gene Order

ENSBTAG00000043987

Not yet available

Pathways

NETPATH

REACTOME

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_2

AndrogenReceptor pathway

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

ar_pathway

Coregulation of Androgen receptor activity

Cross-References

SwissProt

Q8VCD7

TrEMBL

Q3UMI0 Q8BXY9

UniProt Splice Variant

Entrez Gene

76804

UniGene

Mm.405821

RefSeq

NM_001172095 XM_006538350 XM_006538351 XM_006538354 NM_144787 XM_006538352 XM_006538353

OMIM

CCDS

CCDS18287

HPRD

IMGT

MGI ID

MGI:1924054

MGI Symbol

Kdm4c

EMBL

AK042792 AK053104 AK081769 AK144103 AK144890 AK173023 BC020180 BC042424

GenPept

AAH20180 AAH42424 BAC31369 BAC35267 BAC38327 BAD32301 BAE25700 BAE26118

RNA Seq Atlas

76804