InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lipg

Summary

InnateDB Protein

IDBP-158623.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lipg

Protein Name

lipase, endothelial

Synonyms

3110013K01Rik; EL; lipase; mEDL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066536

InnateDB Gene

IDBG-158621 (Lipg)

Protein Structure

UniProt Annotation

Function

Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in placenta, lung, liver, testis and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004465	lipoprotein lipase activity
GO:0004620	phospholipase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008970	phosphatidylcholine 1-acylhydrolase activity

Biological Process

GO:0007584	response to nutrient
GO:0008283	cell proliferation
GO:0010983	positive regulation of high-density lipoprotein particle clearance
GO:0016042	lipid catabolic process
GO:0032376	positive regulation of cholesterol transport
GO:0034375	high-density lipoprotein particle remodeling
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0050746	regulation of lipoprotein metabolic process
GO:0055091	phospholipid homeostasis

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

MGI:1341803

InterPro

IPR000734 Lipase
IPR001024 PLAT/LH2 domain
IPR002330 Lipoprotein lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01477
PF00151

PRINTS

PR00821
PR00822

PIRSF

PIRSF000865

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References