InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Reg3g

Summary

InnateDB Protein

IDBP-158684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Reg3g

Protein Name

regenerating islet-derived 3 gamma

Synonyms

AI449515;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032089

InnateDB Gene

IDBG-158682 (Reg3g)

Protein Structure

UniProt Annotation

Function

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury. {ECO:0000269PubMed:16504538, ECO:0000269PubMed:16931762, ECO:0000269PubMed:17635956, ECO:0000269PubMed:19095652, ECO:0000269PubMed:21998396, ECO:0000269PubMed:22727489, ECO:0000269PubMed:23401489}.

Subcellular Localization

Secreted. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in the small intestine, including Paneth cells (at protein level). Hardly detectable in the colon (at protein level). Highly expressed in the lung epithelium during methicillin-resistant S.aureus infection (at protein level). Skin injury increases its epidermal expression. Also expressed in the pancreas. {ECO:0000269PubMed:16504538, ECO:0000269PubMed:16931762, ECO:0000269PubMed:17635956, ECO:0000269PubMed:21998396, ECO:0000269PubMed:22727489, ECO:0000269PubMed:23401489, ECO:0000269PubMed:9055810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030246	carbohydrate binding

Biological Process

GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006953	acute-phase response
GO:0010838	positive regulation of keratinocyte proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045617	negative regulation of keratinocyte differentiation
GO:0050830	defense response to Gram-positive bacterium
GO:0090303	positive regulation of wound healing