InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hcls1

Summary

InnateDB Protein

IDBP-158690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hcls1

Protein Name

hematopoietic cell specific Lyn substrate 1

Synonyms

AW213261; HS1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023531

InnateDB Gene

IDBG-158688 (Hcls1)

Protein Structure

UniProt Annotation

Function

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed only in tissues and cells of hematopoietic origin.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0003779	actin binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0009725	response to hormone
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030041	actin filament polymerization
GO:0030218	erythrocyte differentiation
GO:0030833	regulation of actin filament polymerization
GO:0030854	positive regulation of granulocyte differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045651	positive regulation of macrophage differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897	positive regulation of protein kinase B signaling
GO:0071345	cellular response to cytokine stimulus
GO:2000107	negative regulation of leukocyte apoptotic process