InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mettl3

Summary

InnateDB Protein

IDBP-158735.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mettl3

Protein Name

methyltransferase like 3

Synonyms

2310024F18Rik; M6A; Spo8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022767

InnateDB Gene

IDBG-158733 (Mettl3)

Protein Structure

UniProt Annotation

Function

N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and self-renewal of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing and processing and mRNA stability. M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding developmental regulators, results in transcript destabilization, maintaining the groung state of ESCs, thereby promoting self-renewal of ESCs. {ECO:0000269PubMed:24209618, ECO:0000269PubMed:24394384}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Note=Colocalizes with speckles in interphase nuclei. Suggesting that it may be associated with nuclear pre-mRNA splicing components (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001734	mRNA (N6-adenosine)-methyltransferase activity
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity

Biological Process

GO:0001510	RNA methylation
GO:0006139	nucleobase-containing compound metabolic process
GO:0006397	mRNA processing
GO:0007623	circadian rhythm
GO:0016556	mRNA modification
GO:0019827	stem cell maintenance
GO:0061157	mRNA destabilization
GO:0080009	mRNA methylation