Version 5.4
Mus musculus Gene: Mettl3
Summary
InnateDB Gene IDBG-158733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mettl3
Gene Name methyltransferase like 3
Synonyms 2310024F18Rik; M6A; Spo8
Species Mus musculus
Ensembl Gene ENSMUSG00000022160
Encoded Proteins
IDBP-158735
methyltransferase like 3
IDBP-531966
methyltransferase like 3
IDBP-620170
methyltransferase like 3
IDBP-620171
methyltransferase like 3
IDBP-620175
methyltransferase like 3
IDBP-620166
methyltransferase like 3
IDBP-620168
methyltransferase like 3
IDBP-620169
methyltransferase like 3
IDBP-620172
methyltransferase like 3
IDBP-620173
methyltransferase like 3
IDBP-620174
methyltransferase like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165819:
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:52294668-52305128
Strand Reverse strand
Band C2
Transcripts
ENSMUST00000022767 ENSMUSP00000022767
ENSMUST00000153539 ENSMUSP00000116141
ENSMUST00000147768 ENSMUSP00000134577
ENSMUST00000130550
ENSMUST00000156611
ENSMUST00000127797
ENSMUST00000122962 ENSMUSP00000133999
ENSMUST00000145875 ENSMUSP00000133573
ENSMUST00000174351 ENSMUSP00000134732
ENSMUST00000173546
ENSMUST00000174360 ENSMUSP00000134578
ENSMUST00000173656 ENSMUSP00000133759
ENSMUST00000173896 ENSMUSP00000133506
ENSMUST00000173138 ENSMUSP00000134018
ENSMUST00000174853 ENSMUSP00000133864
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001734 mRNA (N6-adenosine)-methyltransferase activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0006139 nucleobase-containing compound metabolic process
GO:0006397 mRNA processing
GO:0007623 circadian rhythm
GO:0016556 mRNA modification
GO:0019827 stem cell maintenance
GO:0061157 mRNA destabilization
GO:0080009 mRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0036396 MIS complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000165819
View Gene Order
ENSBTAG00000015148
Not yet available
Pathways
NETPATH
REACTOME
REACT_233572
Gene Expression pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56335
UniGene Mm.271759
RefSeq NM_019721 XM_006519311
OMIM
CCDS CCDS27053
HPRD
IMGT
MGI ID MGI:1927165
MGI Symbol Mettl3
EMBL
GenPept
RNA Seq Atlas 56335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca