InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npy1r

Summary

InnateDB Protein

IDBP-158787.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npy1r

Protein Name

neuropeptide Y receptor Y1

Synonyms

Npyr; Y1-R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045530

InnateDB Gene

IDBG-158785 (Npy1r)

Protein Structure

UniProt Annotation

Function

Receptor for neuropeptide Y and peptide YY.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

The alpha form is highly expressed in the brain, heart, kidney, spleen, skeletal muscle, and lung, whereas the beta receptor mRNA was not detected in these tissues. However, the beta form is expressed in mouse embryonic developmental stage (7 and 11 days), bone marrow cells and several hematopoietic cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0001602	pancreatic polypeptide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity
GO:0005515	protein binding

Biological Process

GO:0003151	outflow tract morphogenesis
GO:0006006	glucose metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007626	locomotory behavior
GO:0007631	feeding behavior
GO:0008217	regulation of blood pressure
GO:0019233	sensory perception of pain
GO:0040014	regulation of multicellular organism growth

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:104963

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000351 Neuropeptide Y1 receptor
IPR000611 Neuropeptide Y receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01013
PR01012

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q04573