InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Npy1r

Summary

InnateDB Gene

IDBG-158785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npy1r

Gene Name

neuropeptide Y receptor Y1

Synonyms

Npyr; Y1-R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000036437

Encoded Proteins

IDBP-158787

neuropeptide Y receptor Y1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164128:
Neuropeptide Y (NPY; MIM 162640) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. Two major subtypes of NPY (Y1 and Y2) have been defined by pharmacologic criteria. NPY receptors, such as NPY1R, have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, and aortic smooth muscle (Herzog et al., 1992 [PubMed 1321422]).[supplied by OMIM, Mar 2008]
This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:66697422-66706798

Strand

Forward strand

Band

B3.1

Transcripts

ENSMUST00000039303

ENSMUSP00000045530

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001601	peptide YY receptor activity
GO:0001602	pancreatic polypeptide receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004983	neuropeptide Y receptor activity
GO:0005515	protein binding

Biological Process

GO:0003151	outflow tract morphogenesis
GO:0006006	glucose metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007626	locomotory behavior
GO:0007631	feeding behavior
GO:0008217	regulation of blood pressure
GO:0019233	sensory perception of pain
GO:0040014	regulation of multicellular organism growth