Version 5.4
Mus musculus Protein: Nat2
Summary
InnateDB Protein IDBP-158903.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nat2
Protein Name N-acetyltransferase 2 (arylamine N-acetyltransferase)
Synonyms AV377607;
Species Mus musculus
Ensembl Protein ENSMUSP00000091181
InnateDB Gene IDBG-158899 (Nat2)
Protein Structure
UniProt Annotation
Function Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:109201
InterPro IPR001447 Arylamine N-acetyltransferase
PFAM PF00797
PRINTS PR01543
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50295
PhosphoSite PhosphoSite-P50295
TrEMBL Q78ZC4
UniProt Splice Variant
Entrez Gene 17961
UniGene Mm.4695
RefSeq NP_001162049
MGI ID
MGI Symbol Nat2
OMIM
CCDS CCDS22338
HPRD
IMGT
EMBL AJ250123 AJ251710 AJ314656 AJ314657 AJ314658 CH466569 U35886 U35887 U37249 U37250
GenPept AAA78943 AAA78944 AAA80353 AAA80354 CAC12845 CAC12846 CAC85415 CAC85416 CAC85417 EDL28705 EDL28706 EDL28707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca