InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tst

Summary

InnateDB Protein

IDBP-159106.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tst

Protein Name

thiosulfate sulfurtransferase, mitochondrial

Synonyms

Rhodanese;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055743

InnateDB Gene

IDBG-159102 (Tst)

Protein Structure

UniProt Annotation

Function

Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Expressed in numerous tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004792	thiosulfate sulfurtransferase activity
GO:0008097	5S rRNA binding

Biological Process

GO:0008152	metabolic process
GO:0030855	epithelial cell differentiation
GO:0035928	rRNA import into mitochondrion
GO:0051029	rRNA transport

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome