InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tyrp1

Summary

InnateDB Protein

IDBP-159180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyrp1

Protein Name

tyrosinase-related protein 1

Synonyms

b; brown; isa; Oca3; TRP-1; TRP1; Tyrp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006151

InnateDB Gene

IDBG-159178 (Tyrp1)

Protein Structure

UniProt Annotation

Function

Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. {ECO:0000269PubMed:7813420}.

Subcellular Localization

Melanosome membrane {ECO:0000269PubMed:17182842}; Single-pass type I membrane protein {ECO:0000269PubMed:17182842}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex.

Disease Associations

Note=Defects in Tyrp1 are the cause of the brown (b) phenotype. Brown mice have a brown or hypopigmented coat.

Tissue Specificity

Pigment cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006582	melanin metabolic process
GO:0006583	melanin biosynthetic process from tyrosine
GO:0008152	metabolic process
GO:0030318	melanocyte differentiation
GO:0032438	melanosome organization
GO:0042438	melanin biosynthetic process
GO:0043438	acetoacetic acid metabolic process
GO:0043473	pigmentation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome