InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tyrp1

Summary

InnateDB Gene

IDBG-159178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyrp1

Gene Name

tyrosinase-related protein 1

Synonyms

b; brown; isa; Oca3; TRP-1; TRP1; Tyrp

Species

Mus musculus

Ensembl Gene

ENSMUSG00000005994

Encoded Proteins

IDBP-159180

tyrosinase-related protein 1

IDBP-159182

tyrosinase-related protein 1

IDBP-538897

tyrosinase-related protein 1

IDBP-538099

tyrosinase-related protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107165:
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:80834123-80851719

Strand

Forward strand

Band

Transcripts

ENSMUST00000006151	ENSMUSP00000006151
ENSMUST00000102831	ENSMUSP00000099895
ENSMUST00000133655	ENSMUSP00000117080
ENSMUST00000133932	ENSMUSP00000119167

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006582	melanin metabolic process
GO:0006583	melanin biosynthetic process from tyrosine
GO:0008152	metabolic process
GO:0030318	melanocyte differentiation
GO:0032438	melanosome organization
GO:0042438	melanin biosynthetic process
GO:0043438	acetoacetic acid metabolic process
GO:0043473	pigmentation
GO:0055114	oxidation-reduction process

Cellular Component

GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0033162	melanosome membrane
GO:0042470	melanosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000107165

View Gene Order

ENSBTAG00000020985

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00350

Tyrosine metabolism pathway

mmu04916

Melanogenesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00350

Tyrosine metabolism pathway

hsa04916

Melanogenesis pathway

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

Cross-References

SwissProt

P07147

TrEMBL

A2ADJ4 A2ADJ6 Q3UFS3

UniProt Splice Variant

Entrez Gene

22178

UniGene

Mm.30438 Mm.412291

RefSeq

NM_001282014 NM_001282015 NM_031202

OMIM

CCDS

CCDS18290

HPRD

IMGT

MGI ID

MGI:98881

MGI Symbol

Tyrp1

EMBL

AK148332 AL670884 BC076598 CH466527 X03687

GenPept

AAH76598 BAE28487 CAA27323 CAM22449 CAM22450 CAM22451 EDL31046

RNA Seq Atlas

22178