InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amica1

Summary

InnateDB Protein

IDBP-159200.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amica1

Protein Name

adhesion molecule, interacts with CXADR antigen 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052033

InnateDB Gene

IDBG-159198 (Amica1)

Protein Structure

UniProt Annotation

Function

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T- cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T- cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269PubMed:20813954}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:20813954}; Single-pass type I membrane protein {ECO:0000269PubMed:20813954}. Cell junction {ECO:0000250}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed by gamma-delta intraepithelial T cells (at protein level). {ECO:0000269PubMed:20813954}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0007157	heterophilic cell-cell adhesion
GO:0030593	neutrophil chemotaxis
GO:0035696	monocyte extravasation
GO:0046629	gamma-delta T cell activation
GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing
GO:0072672	neutrophil extravasation

Cellular Component

GO:0005886	plasma membrane
GO:0005923	tight junction
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2685484

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00406
SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80UL9