InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abi2

Summary

InnateDB Protein

IDBP-159326.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abi2

Protein Name

abl-interactor 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058754

InnateDB Gene

IDBG-159322 (Abi2)

Protein Structure

UniProt Annotation

Function

May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. {ECO:0000269PubMed:15143189}.

Subcellular Localization

Cytoplasm. Cell projection, lamellipodium. Cell projection, filopodium. Cytoplasm, cytoskeleton. Note=Localized to protruding lamellipodia and filopodia tips.

Disease Associations

Tissue Specificity

Expresses in embryonic and adult brain. In adult brain prominently expressed in the neocortex, hippocampus and dentate gyrus. {ECO:0000269PubMed:10995551}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007611	learning or memory
GO:0008154	actin polymerization or depolymerization
GO:0016358	dendrite development
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043010	camera-type eye development

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005913	cell-cell adherens junction
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030425	dendrite