InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sstr3

Summary

InnateDB Protein

IDBP-159484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sstr3

Protein Name

somatostatin receptor 3

Synonyms

Smstr-3; Smstr3; sst3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000058040

InnateDB Gene

IDBG-159482 (Sstr3)

Protein Structure

UniProt Annotation

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. {ECO:0000269PubMed:1328199}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized into endoplasmic vesicles upon somatostatin-stimulation. {ECO:0000250}.

Disease Associations

Tissue Specificity

In the brain, primarily observed in the forebrain. Moderate levels found throughout laminae 2-6 of the neocortex and allocortex, and high levels in lamina 2 of the piriform and entorhinal cortices. High levels also present in the cornu ammonis fields of the hippocampus. In the amygdala, highly expressed in the nucleus of the lateral olfactory tract with expression also detected in the rostral portions of the basal magnocellular and lateral nuclei. In the diencephalon, moderate levels observed in the ventromedial and arcuate nuclei of the hypothalamus. In the midbrain, moderate levels found in the lateral portion of the substantia nigra pars reticulata. {ECO:0000269PubMed:1328199}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004994	somatostatin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0021549	cerebellum development
GO:0030900	forebrain development
GO:0038170	somatostatin signaling pathway
GO:0042594	response to starvation
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0016021	integral component of membrane
GO:0031513	nonmotile primary cilium
GO:0060170	ciliary membrane

Protein Structure and Domains

PDB ID

MGI:98329

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000586 Somatostatin receptor family
IPR001856 Somatostatin receptor 3
IPR009150 Neuropeptide B/W receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10323
PF10328

PRINTS

PR00237
PR00246
PR00589
PR01855

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30935