InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rac2

Summary

InnateDB Protein

IDBP-159516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rac2

Protein Name

RAS-related C3 botulinum substrate 2

Synonyms

AI323801; AI452260;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036384

InnateDB Gene

IDBG-159514 (Rac2)

Protein Structure

UniProt Annotation

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Membrane- associated when activated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0015031	protein transport
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0060263	regulation of respiratory burst

Cellular Component

GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97846

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt