InnateDB Protein
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IDBP-15963.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OGG1
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Protein Name
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8-oxoguanine DNA glycosylase
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Synonyms
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HMMH; HOGG1; MUTM; OGH1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303132
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InnateDB Gene
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IDBG-15945 (OGG1)
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Protein Structure
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Function |
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.
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Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000269PubMed:17148573}. Nucleus speckle {ECO:0000269PubMed:17148573}. Nucleus matrix {ECO:0000269PubMed:17148573}. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.Isoform 1A: Nucleus.Isoform 2A: Mitochondrion.
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Disease Associations |
Renal cell carcinoma (RCC) [MIM:144700]: Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Clear cell renal cell carcinoma is the most common subtype. Note=The disease may be caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
15
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003265
HhH-GPD domain
IPR011257
DNA glycosylase
IPR012904
8-oxoguanine DNA glycosylase, N-terminal
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PFAM |
PF00730
PF07934
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PRINTS |
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PIRSF |
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SMART |
SM00478
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TIGRFAMs |
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Modification |
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SwissProt |
O15527
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PhosphoSite |
PhosphoSite-O15527
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TrEMBL |
E5KPM6
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UniProt Splice Variant |
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Entrez Gene |
4968
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UniGene |
Hs.736214
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RefSeq |
NP_058434
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HUGO |
HGNC:8125
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OMIM |
601982
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CCDS |
CCDS2577
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HPRD |
03582
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IMGT |
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EMBL |
AB000410
AB019528
AB019529
AB019530
AB019531
AB019532
AC022382
AF003595
AF026691
AF088282
AF521807
AJ131341
AK289858
BC000657
CH471055
HQ205506
HQ205507
HQ205508
HQ205509
HQ205510
HQ205511
HQ205512
HQ205513
HQ205514
HQ205515
HQ205516
HQ205517
HQ205518
HQ205519
HQ205520
HQ205521
HQ205522
HQ205523
HQ205524
HQ205525
HQ205526
HQ205527
HQ205528
HQ205529
HQ205530
HQ205531
HQ205532
HQ205533
HQ205534
HQ205535
HQ205536
HQ205537
HQ205538
HQ205539
HQ205540
HQ205541
HQ205542
HQ205543
HQ205544
HQ205545
U88527
U88620
U96710
Y11731
Y11838
Y13277
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GenPept |
AAB61340
AAB68614
AAB68615
AAB81132
AAB84013
AAD41680
AAD41681
AAD41682
AAH00657
AAM74236
ADQ20118
ADQ20125
ADQ20132
ADQ20139
ADQ20146
ADQ20153
ADQ20160
ADQ20167
ADQ20174
ADQ20181
ADQ20188
ADQ20195
ADQ20202
ADQ20209
ADQ20216
ADQ20223
ADQ20230
ADQ20237
ADQ20244
ADQ20251
ADQ20258
ADQ20265
ADQ20272
ADQ20279
ADQ20286
ADQ20293
ADQ20300
ADQ20307
ADQ20314
ADQ20321
ADQ20328
ADQ20335
ADQ20342
ADQ20349
ADQ20356
ADQ20363
ADQ20370
ADQ20377
ADQ20384
ADQ20391
BAA19103
BAA76635
BAA76636
BAA76637
BAA76638
BAA76639
BAF82547
CAA10351
CAA72414
CAA72536
CAA73726
EAW63988
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