InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OGG1

Summary

InnateDB Gene

IDBG-15945.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OGG1

Gene Name

8-oxoguanine DNA glycosylase

Synonyms

HMMH; HOGG1; MUTM; OGH1

Species

Homo sapiens

Ensembl Gene

ENSG00000114026

Encoded Proteins

IDBP-15947

8-oxoguanine DNA glycosylase

IDBP-15953

8-oxoguanine DNA glycosylase

IDBP-15955

8-oxoguanine DNA glycosylase

IDBP-15957

8-oxoguanine DNA glycosylase

IDBP-15959

8-oxoguanine DNA glycosylase

IDBP-15961

8-oxoguanine DNA glycosylase

IDBP-15963

8-oxoguanine DNA glycosylase

IDBP-15965

8-oxoguanine DNA glycosylase

IDBP-361734

8-oxoguanine DNA glycosylase

IDBP-361750

8-oxoguanine DNA glycosylase

IDBP-361752

8-oxoguanine DNA glycosylase

IDBP-361753

8-oxoguanine DNA glycosylase

IDBP-361760

8-oxoguanine DNA glycosylase

IDBP-361769

8-oxoguanine DNA glycosylase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:9749944-9788219

Strand

Forward strand

Band

p25.3

Transcripts

ENST00000302003	ENSP00000305584
ENST00000383826	ENSP00000373337
ENST00000339511	ENSP00000345520
ENST00000344629	ENSP00000342851
ENST00000302008	ENSP00000305527
ENST00000302036	ENSP00000306561
ENST00000349503	ENSP00000303132
ENST00000352937	ENSP00000344899
ENST00000383825
ENST00000449570	ENSP00000403598
ENST00000436092
ENST00000425665	ENSP00000396034
ENST00000441094	ENSP00000390337
ENST00000429146	ENSP00000393726
ENST00000426518	ENSP00000399810
ENST00000432857
ENST00000416333	ENSP00000402713
ENST00000602976

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	12 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0004519	endonuclease activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0019104	DNA N-glycosylase activity
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0002526	acute inflammatory response
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0009314	response to radiation
GO:0032355	response to estradiol
GO:0033158	regulation of protein import into nucleus, translocation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045007	depurination
GO:0045471	response to ethanol
GO:0051593	response to folic acid
GO:0071276	cellular response to cadmium ion
GO:0090305	nucleic acid phosphodiester bond hydrolysis