Version 5.4
Mus musculus Protein: Mpg
Summary
InnateDB Protein IDBP-159712.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mpg
Protein Name N-methylpurine-DNA glycosylase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000020528
InnateDB Gene IDBG-159710 (Mpg)
Protein Structure
UniProt Annotation
Function Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.
Subcellular Localization Cytoplasm {ECO:0000250}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
GO:0005515 protein binding
GO:0008725 DNA-3-methyladenine glycosylase activity
GO:0043916 DNA-7-methylguanine glycosylase activity
GO:0052821 DNA-7-methyladenine glycosylase activity
GO:0052822 DNA-3-methylguanine glycosylase activity
Biological Process
GO:0006284 base-excision repair
Cellular Component
GO:0005634 nucleus
GO:0042645 mitochondrial nucleoid
Protein Structure and Domains
PDB ID MGI:97073
InterPro IPR003180 Methylpurine-DNA glycosylase (MPG)
IPR011034 Formyl transferase, C-terminal-like
PFAM PF02245
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q04841
PhosphoSite PhosphoSite-Q04841
TrEMBL Q8VIJ9
UniProt Splice Variant
Entrez Gene 268395
UniGene Mm.263161
RefSeq NP_034952
MGI ID
MGI Symbol Mpg
OMIM
CCDS CCDS24520
HPRD
IMGT
EMBL AL929446 AY016021 BC014754 M99625 S81120 S81133 S81134 S81162 U10420 X74509 X75038 X75039 X75040
GenPept AAA02577 AAA19487 AAH14754 AAL32368 CAA52615 CAM16547

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca