InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Icos

Summary

InnateDB Protein

IDBP-159741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Icos

Protein Name

inducible T-cell co-stimulator

Synonyms

AILIM; CCLP; CRP-1; H4; Ly115;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099891

InnateDB Gene

IDBG-159737 (Icos)

Protein Structure

UniProt Annotation

Function

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen. {ECO:0000269PubMed:10617205, ECO:0000269PubMed:10760791, ECO:0000269PubMed:11006126}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.