Version 5.4
Mus musculus Gene: Icos
Summary
InnateDB Gene IDBG-159737.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Icos
Gene Name inducible T cell co-stimulator
Synonyms AILIM; CCLP; CRP-1; H4; Ly115
Species Mus musculus
Ensembl Gene ENSMUSG00000026009
Encoded Proteins
IDBP-159739
inducible T-cell co-stimulator
IDBP-159741
inducible T-cell co-stimulator
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163600:
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:60977927-61000320
Strand Forward strand
Band C2
Transcripts
ENSMUST00000027162 ENSMUSP00000027162
ENSMUST00000102827 ENSMUSP00000099891
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002517 T cell tolerance induction
GO:0016337 single organismal cell-cell adhesion
GO:0031295 T cell costimulation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163600
View Gene Order
ENSBTAG00000021596
Not yet available
Pathways
NETPATH
REACTOME
REACT_230745
Immune System pathway
REACT_225477
Costimulation by the CD28 family pathway
REACT_229531
Adaptive Immune System pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05340
Primary immunodeficiency pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_213843
Costimulation by the CD28 family pathway
REACT_213138
Immune System pathway
REACT_214469
Adaptive Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04660
T cell receptor signaling pathway pathway
hsa05340
Primary immunodeficiency pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.42044
RefSeq NM_017480 XM_006496138 XM_006496139 XM_006496140 XM_006536905 XM_006536906
OMIM
CCDS CCDS14994
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca