Version 5.4
Mus musculus Protein: Srsf3
Summary
InnateDB Protein IDBP-159794.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srsf3
Protein Name serine/arginine-rich splicing factor 3
Synonyms AL024116; Sfrs3; X16;
Species Mus musculus
Ensembl Protein ENSMUSP00000049025
InnateDB Gene IDBG-159792 (Srsf3)
Protein Structure
UniProt Annotation
Function May be involved in RNA processing in relation with cellular proliferation and/or maturation. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. RNA-binding is semi-sequence specific (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Highest expression in thymus and pre-B cell lines; high, in testis, brain and spleen; very low in heart and not detectable in liver and kidney. {ECO:0000269PubMed:2030943}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0043274 phospholipase binding
Biological Process
GO:0006397 mRNA processing
GO:0008286 insulin receptor signaling pathway
GO:0008380 RNA splicing
GO:0051028 mRNA transport
Cellular Component
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID MGI:98285
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P84104
PhosphoSite PhosphoSite-P84104
TrEMBL Q3U781
UniProt Splice Variant
Entrez Gene 20383
UniGene Mm.6787
RefSeq
MGI ID 2I2Y
MGI Symbol Srsf3
OMIM
CCDS
HPRD
IMGT
EMBL AK011657 AK078891 AK134177 AK135298 AK145089 AK145715 AK146010 AK146253 AK150912 AK152411 AK152779 AK153073 AK153209 BC068111 BC071196 BC083316 CH466606 X53824 X91656
GenPept AAH68111 AAH71196 AAH83316 BAB27762 BAC37445 BAE22040 BAE22483 BAE26230 BAE26606 BAE26830 BAE27015 BAE29950 BAE31197 BAE31490 BAE31698 BAE31808 CAA37821 CAA62844 CAA62845 EDL22603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca