Version 5.4
Mus musculus Gene: Srsf3
Summary
InnateDB Gene IDBG-159792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Srsf3
Gene Name serine/arginine-rich splicing factor 3
Synonyms AL024116; Sfrs3; X16
Species Mus musculus
Ensembl Gene ENSMUSG00000071172
Encoded Proteins
IDBP-159794
serine/arginine-rich splicing factor 3
IDBP-542795
serine/arginine-rich splicing factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:29032673-29043366
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000037776 ENSMUSP00000049025
ENSMUST00000130216 ENSMUSP00000117045
ENSMUST00000147265
ENSMUST00000144551
ENSMUST00000150157
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 93 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0043274 phospholipase binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008286 insulin receptor signaling pathway
GO:0008380 RNA splicing
GO:0051028 mRNA transport
Cellular Component
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112081
View Gene Order
ENSBTAG00000040006
Not yet available
Pathways
NETPATH
REACTOME
REACT_240247
mRNA 3'-end processing pathway
REACT_237682
Transport of Mature Transcript to Cytoplasm pathway
REACT_249110
mRNA Splicing pathway
REACT_257346
RNA Polymerase II Transcription Termination pathway
REACT_253727
Cleavage of Growing Transcript in the Termination Region pathway
REACT_233572
Gene Expression pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_232353
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
KEGG
mmu03040
Spliceosome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1849
mRNA 3'-end processing pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1597
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_387
Cleavage of Growing Transcript in the Termination Region pathway
REACT_894
RNA Polymerase II Transcription Termination pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_1281
Transport of Mature Transcript to Cytoplasm pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_224643
Cleavage of Growing Transcript in the Termination Region pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_203211
mRNA 3'-end processing pathway
REACT_224602
Transport of Mature Transcript to Cytoplasm pathway
REACT_224606
RNA Polymerase II Transcription Termination pathway
REACT_226022
Gene Expression pathway
REACT_220982
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt P84104
TrEMBL Q3U781
UniProt Splice Variant
Entrez Gene 20383
UniGene Mm.396498 Mm.429307 Mm.6787
RefSeq NM_013663
OMIM
CCDS CCDS28590
HPRD
IMGT
MGI ID MGI:98285
MGI Symbol Srsf3
EMBL AK011657 AK078891 AK134177 AK135298 AK145089 AK145715 AK146010 AK146253 AK150912 AK152411 AK152779 AK153073 AK153209 BC068111 BC071196 BC083316 CH466606 X53824 X91656
GenPept AAH68111 AAH71196 AAH83316 BAB27762 BAC37445 BAE22040 BAE22483 BAE26230 BAE26606 BAE26830 BAE27015 BAE29950 BAE31197 BAE31490 BAE31698 BAE31808 CAA37821 CAA62844 CAA62845 EDL22603
RNA Seq Atlas 20383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca