Version 5.4
Mus musculus Protein: Lzts1
Summary
InnateDB Protein IDBP-159885.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lzts1
Protein Name leucine zipper, putative tumor suppressor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000039397
InnateDB Gene IDBG-159883 (Lzts1)
Protein Structure
UniProt Annotation
Function Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0014069 postsynaptic density
GO:0030054 cell junction
GO:0043197 dendritic spine
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2684762
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P60853
PhosphoSite PhosphoSite-P60853
TrEMBL
UniProt Splice Variant
Entrez Gene 211134
UniGene Mm.479807
RefSeq NP_955396
MGI ID
MGI Symbol Lzts1
OMIM
CCDS CCDS22345
HPRD
IMGT
EMBL AF288601 BC139350 BC139352
GenPept AAI39351 AAI39353 AAQ14349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca