Version 5.4
Mus musculus Gene: Lzts1
Summary
InnateDB Gene IDBG-159883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lzts1
Gene Name leucine zipper, putative tumor suppressor 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000036306
Encoded Proteins
IDBP-159885
leucine zipper, putative tumor suppressor 1
IDBP-789292
leucine zipper, putative tumor suppressor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061337:
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:69132669-69184225
Strand Reverse strand
Band B3.3
Transcripts
ENSMUST00000037049 ENSMUSP00000039397
ENSMUST00000185176 ENSMUSP00000139117
ENSMUST00000184961
ENSMUST00000184061
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007049 cell cycle
GO:0016242 negative regulation of macroautophagy
GO:0048814 regulation of dendrite morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0014069 postsynaptic density
GO:0016324 apical plasma membrane
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0044297 cell body
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000061337
View Gene Order
ENSBTAG00000000841
Not yet available
Cross-References
SwissProt P60853
TrEMBL
UniProt Splice Variant
Entrez Gene 211134
UniGene
RefSeq XM_006509606 XM_006509607 XM_006509608 NM_199364
OMIM
CCDS CCDS22345
HPRD
IMGT
MGI ID MGI:2684762
MGI Symbol Lzts1
EMBL AF288601 BC139350 BC139352
GenPept AAI39351 AAI39353 AAQ14349
RNA Seq Atlas 211134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca