InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tlx2

Summary

InnateDB Protein

IDBP-159909.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tlx2

Protein Name

T-cell leukemia, homeobox 2

Synonyms

Enx; Hox11L.1; Hox11l1; NCX; Ncx1; Tlx1l1; Tlx1l2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087069

InnateDB Gene

IDBG-159907 (Tlx2)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract. {ECO:0000269PubMed:10869550, ECO:0000269PubMed:17560225, ECO:0000269PubMed:19697050}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001707	mesoderm formation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0048484	enteric nervous system development
GO:0050774	negative regulation of dendrite morphogenesis