Version 5.4
Mus musculus Gene: Tlx2
Summary
InnateDB Gene IDBG-159907.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tlx2
Gene Name T cell leukemia, homeobox 2
Synonyms Enx; Hox11L.1; Hox11l1; NCX; Ncx1; Tlx1l1; Tlx1l2
Species Mus musculus
Ensembl Gene ENSMUSG00000068327
Encoded Proteins
IDBP-159909
T-cell leukemia, homeobox 2
IDBP-620083
T-cell leukemia, homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115297:
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:83068324-83070225
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000089641 ENSMUSP00000087069
ENSMUST00000174674 ENSMUSP00000133420
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001707 mesoderm formation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0048484 enteric nervous system development
GO:0050774 negative regulation of dendrite morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115297
View Gene Order
ENSBTAG00000016607
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
alk2pathway
ALK2 signaling events
alk1pathway
ALK1 signaling events
Cross-References
SwissProt Q61663
TrEMBL G3UWU0
UniProt Splice Variant
Entrez Gene 21909
UniGene Mm.37
RefSeq NM_009392
OMIM
CCDS CCDS20269
HPRD
IMGT
MGI ID MGI:1350935
MGI Symbol Tlx2
EMBL AC104324 BC138240 BC138241 CH466523 M75953
GenPept AAA37805 AAI38241 AAI38242 EDK99054 EDK99055
RNA Seq Atlas 21909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca