Mus musculus Protein: Atp5a1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-160172.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Atp5a1 | ||||||||||||||||||||||
Protein Name | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 | ||||||||||||||||||||||
Synonyms | AI035633; AL022851; AL023067; Atpm; D18Ertd206e; Mom2; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000026495 | ||||||||||||||||||||||
InnateDB Gene | IDBG-160170 (Atp5a1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Mitochondrion inner membrane {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Colocalizes with HRG on the cell surface of T-cells. {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:88115 | ||||||||||||||||||||||
InterPro |
IPR000194
ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain IPR005294 ATPase, F1 complex, alpha subunit IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00006
PF00306 PF02874 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART | |||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q03265 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q03265 | ||||||||||||||||||||||
TrEMBL | D3Z6F5 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 11946 | ||||||||||||||||||||||
UniGene | Mm.276137 | ||||||||||||||||||||||
RefSeq | NP_031531 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Atp5a1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS29358 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC162291 AK043976 AK076572 AK146797 AK150426 AK150843 AK151004 AK151128 AK151224 AK151920 AK152054 AK152890 AK157529 AK159491 AK159540 AK159758 AK160043 AK164110 AK164193 AK166709 AK166812 AK167159 AK167863 AK168198 AK168617 AK168879 AK168890 AK168932 AK169080 AK169084 AK169105 AK169142 AK169300 AK169308 AK169414 BC014854 CH466528 L01062 | ||||||||||||||||||||||
GenPept | AAA37271 AAH14854 BAC31722 BAC36399 BAE27439 BAE29549 BAE29901 BAE30027 BAE30136 BAE30216 BAE30798 BAE30910 BAE31573 BAE34114 BAE35125 BAE35167 BAE35349 BAE35585 BAE37632 BAE37675 BAE38962 BAE39039 BAE39300 BAE39881 BAE40158 BAE40482 BAE40697 BAE40707 BAE40744 BAE40864 BAE40868 BAE40887 BAE40921 BAE41056 BAE41063 BAE41160 EDL09448 | ||||||||||||||||||||||