InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bace1

Summary

InnateDB Protein

IDBP-160175.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Bace1

Protein Name

beta-site APP cleaving enzyme 1

Synonyms

C76936;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077249

InnateDB Gene

IDBG-160173 (Bace1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0016020	membrane
GO:0030424	axon
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:1346542

InterPro

IPR001461 Aspartic peptidase
IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR021109 Aspartic peptidase domain

PFAM

PF00026

PRINTS

PR00792
PR01815
PR01816

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite