InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bace1

Summary

InnateDB Protein

IDBP-160177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bace1

Protein Name

beta-site APP cleaving enzyme 1

Synonyms

C76936;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034591

InnateDB Gene

IDBG-160173 (Bace1)

Protein Structure

UniProt Annotation

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Endosome {ECO:0000250}. Cell surface {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0019899	enzyme binding

Biological Process

GO:0006508	proteolysis
GO:0050435	beta-amyloid metabolic process

Cellular Component

GO:0005768	endosome
GO:0005770	late endosome
GO:0005771	multivesicular body
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030424	axon
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:1346542

InterPro

IPR001461 Aspartic peptidase
IPR009119 Peptidase A1, beta-site APP cleaving enzyme, BACE
IPR009120 Peptidase A1, beta-site APP cleaving enzyme 1, BACE 1
IPR021109 Aspartic peptidase domain

PFAM

PF00026

PRINTS

PR00792
PR01815
PR01816

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P56818