InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arid5b

Summary

InnateDB Protein

IDBP-160190.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arid5b

Protein Name

AT rich interactive domain 5B (MRF1-like)

Synonyms

4930580B11; 5430435G07Rik; AI467247; Desrt; Mrf2; Mrf2alpha; Mrf2beta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020106

InnateDB Gene

IDBG-160188 (Arid5b)

Protein Structure

UniProt Annotation

Function

Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. {ECO:0000250, ECO:0000269PubMed:12215486, ECO:0000269PubMed:14651970, ECO:0000269PubMed:17962384, ECO:0000269PubMed:18070594, ECO:0000269PubMed:19913508}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00355, ECO:0000269PubMed:12215486}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed in lung, heart, small intestine, kidney, muscle and brain. Also expressed in spleen, thymus, endocrine organs and in uterus and testis. {ECO:0000269PubMed:11483573, ECO:0000269PubMed:12215486}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001822	kidney development
GO:0006351	transcription, DNA-templated
GO:0006807	nitrogen compound metabolic process
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0009791	post-embryonic development
GO:0010761	fibroblast migration
GO:0030325	adrenal gland development
GO:0035264	multicellular organism growth
GO:0045444	fat cell differentiation
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048468	cell development
GO:0048644	muscle organ morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0060612	adipose tissue development
GO:0060613	fat pad development