Version 5.4
Mus musculus Gene: Arid5b
Summary
InnateDB Gene IDBG-160188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arid5b
Gene Name AT rich interactive domain 5B (MRF1-like)
Synonyms 4930580B11; 5430435G07Rik; AI467247; Desrt; Mrf2; Mrf2alpha; Mrf2beta
Species Mus musculus
Ensembl Gene ENSMUSG00000019947
Encoded Proteins
IDBP-160190
AT rich interactive domain 5B (MRF1-like)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150347:
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:68095593-68278726
Strand Reverse strand
Band B5.2
Transcripts
ENSMUST00000020106 ENSMUSP00000020106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0001822 kidney development
GO:0006351 transcription, DNA-templated
GO:0006807 nitrogen compound metabolic process
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009791 post-embryonic development
GO:0010761 fibroblast migration
GO:0030325 adrenal gland development
GO:0035264 multicellular organism growth
GO:0045444 fat cell differentiation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048468 cell development
GO:0048644 muscle organ morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060021 palate development
GO:0060325 face morphogenesis
GO:0060612 adipose tissue development
GO:0060613 fat pad development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000150347
View Gene Order
ENSBTAG00000006729
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_256030
HDMs demethylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8BM75
TrEMBL
UniProt Splice Variant
Entrez Gene 71371
UniGene Mm.397874
RefSeq NM_023598 XM_006514129 XM_006514132
OMIM
CCDS CCDS35929
HPRD
IMGT
MGI ID MGI:2175912
MGI Symbol Arid5b
EMBL AC122293 AC132588 AF169968 AF280065 AF401550 AK017396 AK031596 AK034633
GenPept AAF89682 AAM93269 AAM93282 BAB30727 BAC27467 BAC28778
RNA Seq Atlas 71371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca