InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Maged1

Summary

InnateDB Protein

IDBP-160249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maged1

Protein Name

melanoma antigen, family D, 1

Synonyms

2810433C11Rik; 5430405L04Rik; Dlixin; Dlxin-1; Dlxin1; DXBwg1492e; MAGE-D1; mFLJ00163; NRAGE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026142

InnateDB Gene

IDBG-160245 (Maged1)

Protein Structure

UniProt Annotation

Function

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA coregulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269PubMed:20300063}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:20300063}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed in many adult tissues, except for the spleen. Expressed in osteoblastic and chondrogenic cell lines and also during embryonic development.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043406	positive regulation of MAP kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050680	negative regulation of epithelial cell proliferation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:2001235	positive regulation of apoptotic signaling pathway