InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sptlc2

Summary

InnateDB Protein

IDBP-160281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sptlc2

Protein Name

serine palmitoyltransferase, long chain base subunit 2

Synonyms

AI173915; LCB2; mKIAA0526;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021424

InnateDB Gene

IDBG-160279 (Sptlc2)

Protein Structure

UniProt Annotation

Function

Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:1317856}; Single-pass membrane protein {ECO:0000269PubMed:1317856}.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004758	serine C-palmitoyltransferase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006686	sphingomyelin biosynthetic process
GO:0009058	biosynthetic process
GO:0046511	sphinganine biosynthetic process
GO:0046512	sphingosine biosynthetic process
GO:0046513	ceramide biosynthetic process