InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Numbl

Summary

InnateDB Protein

IDBP-160324.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Numbl

Protein Name

numb-like

Synonyms

nbl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078245

InnateDB Gene

IDBG-160322 (Numbl)

Protein Structure

UniProt Annotation

Function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. {ECO:0000269PubMed:12410312, ECO:0000269PubMed:15273690, ECO:0000269PubMed:17174898, ECO:0000269PubMed:9169836}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9169836}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS.

Disease Associations

Tissue Specificity

Preferentially expressed in the nervous system. In the developing neocortex, expressed in postmitotic neurons in the cortical plate but not in progenitors within the ventricular zone. {ECO:0000269PubMed:9169836}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007399	nervous system development
GO:0007405	neuroblast proliferation
GO:0007409	axonogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0019538	protein metabolic process
GO:0021670	lateral ventricle development
GO:0021849	neuroblast division in subventricular zone
GO:0030900	forebrain development
GO:0034332	adherens junction organization
GO:0050769	positive regulation of neurogenesis
GO:0050775	positive regulation of dendrite morphogenesis