Version 5.4
| Mus musculus Protein: Fgd2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-160624.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Fgd2 | ||||||||
| Protein Name | FYVE, RhoGEF and PH domain containing 2 | ||||||||
| Synonyms | Tcd-2; Tcd2; tcs-2; tcs2; ZFYVE4; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000024810 | ||||||||
| InnateDB Gene | IDBG-160622 (Fgd2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. {ECO:0000269Ref.2}. | ||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269Ref.2}. Nucleus {ECO:0000269Ref.2}. Early endosome {ECO:0000269Ref.2}. Early endosome membrane {ECO:0000269Ref.2}. Cell projection, ruffle membrane {ECO:0000269Ref.2}. Cytoplasm, cytoskeleton {ECO:0000305Ref.2}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Lymph node, spleen, B-lymphocytes and macrophages (at protein level). Expressed at high levels in lymph node, spleen, B-lymphocytes and bone marrow macrophages. Expressed at lower levels in mature bone marrow dendritic cells. In both immature and mature B-cells, expression is down-regulated by prior B-cell receptor signaling. Expression remains high in resting B and memory cells but declines upon differentiation into plasma cells. {ECO:0000269PubMed:10458911, ECO:0000269Ref.2}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1347084 | ||||||||
| InterPro |
IPR000219
Dbl homology (DH) domain IPR000306 FYVE zinc finger IPR001849 Pleckstrin homology domain IPR011011 Zinc finger, FYVE/PHD-type IPR017455 Zinc finger, FYVE-related |
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| PFAM |
PF00621
PF01363 PF00169 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00325
SM00064 SM00233 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8BY35 | ||||||||
| PhosphoSite | PhosphoSite-Q8BY35 | ||||||||
| TrEMBL | B2XXT3 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 26382 | ||||||||
| UniGene | Mm.279187 | ||||||||
| RefSeq | NP_038738 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Fgd2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS37537 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF017368 AK042260 AK156151 AY301264 BC021845 DQ344523 EU288040 EU288041 EU288042 EU288043 EU288044 EU288045 EU288049 EU288050 | ||||||||
| GenPept | AAC35430 AAH21845 AAP45199 AAP45200 ABC70180 ABY59066 ABY59067 ABY59068 ABY59069 ABY59070 ABY59071 ABY59075 ABY59076 BAC31206 BAE33605 | ||||||||