InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: St6galnac6

Summary

InnateDB Protein

IDBP-160633.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

St6galnac6

Protein Name

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Synonyms

Siat7f; ST6GalNAcVI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071983

InnateDB Gene

IDBG-160625 (St6galnac6)

Protein Structure

UniProt Annotation

Function

Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in kidney. {ECO:0000269PubMed:10702226}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10702226}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0001574	ganglioside biosynthetic process
GO:0006486	protein glycosylation
GO:0006677	glycosylceramide metabolic process
GO:0009312	oligosaccharide biosynthetic process
GO:0009988	cell-cell recognition
GO:0097503	sialylation