InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ank3

Summary

InnateDB Protein

IDBP-160653.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ank3

Protein Name

ankyrin 3, epithelial

Synonyms

2900054D09Rik; AI314020; Ank-3; AnkG; Ankyrin-3; Ankyrin-G;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090090

InnateDB Gene

IDBG-160651 (Ank3)

Protein Structure

UniProt Annotation

Function

Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. {ECO:0000250, ECO:0000269PubMed:19109891}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Lysosome. Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In bone marrow-derived macrophages, isoforms 2 and 3 are associated with lysosomes.

Disease Associations

Tissue Specificity

Expressed in many epithelial tissues, muscles and axons. Expressed in kidney, brain, skin, lung, liver, intestine, pancreas, heart and testis (at protein level). In testis, expressed in Leydig cells, but very weakly or not at all in Sertoli cells or seminiferous tubules. Expressed in macrophages (at protein level). {ECO:0000269PubMed:7615634, ECO:0000269PubMed:9060470}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007165	signal transduction
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007528	neuromuscular junction development
GO:0010650	positive regulation of cell communication by electrical coupling
GO:0019228	neuronal action potential
GO:0034112	positive regulation of homotypic cell-cell adhesion
GO:0043001	Golgi to plasma membrane protein transport
GO:0045760	positive regulation of action potential
GO:0050808	synapse organization
GO:0071709	membrane assembly
GO:0072659	protein localization to plasma membrane
GO:0072660	maintenance of protein location in plasma membrane
GO:0072661	protein targeting to plasma membrane
GO:0090314	positive regulation of protein targeting to membrane

Cellular Component

GO:0005764	lysosome
GO:0005856	cytoskeleton
GO:0005923	tight junction
GO:0009925	basal plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016328	lateral plasma membrane
GO:0016529	sarcoplasmic reticulum
GO:0030018	Z disc
GO:0030424	axon
GO:0030425	dendrite
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier
GO:0033270	paranode region of axon
GO:0042383	sarcolemma
GO:0043194	axon initial segment
GO:0045202	synapse
GO:0045211	postsynaptic membrane