Version 5.4
Mus musculus Gene: Ank3
Summary
InnateDB Gene IDBG-160651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ank3
Gene Name ankyrin 3, epithelial
Synonyms 2900054D09Rik; AI314020; Ank-3; AnkG; Ankyrin-3; Ankyrin-G
Species Mus musculus
Ensembl Gene ENSMUSG00000069601
Encoded Proteins
IDBP-160653
ankyrin 3, epithelial
IDBP-160655
ankyrin 3, epithelial
IDBP-160657
ankyrin 3, epithelial
IDBP-160659
ankyrin 3, epithelial
IDBP-160661
ankyrin 3, epithelial
IDBP-160665
ankyrin 3, epithelial
IDBP-790195
ankyrin 3, epithelial
IDBP-790196
ankyrin 3, epithelial
IDBP-790197
ankyrin 3, epithelial
IDBP-790198
ankyrin 3, epithelial
IDBP-790199
ankyrin 3, epithelial
IDBP-790200
ankyrin 3, epithelial
IDBP-790201
ankyrin 3, epithelial
IDBP-790202
ankyrin 3, epithelial
IDBP-790203
ankyrin 3, epithelial
IDBP-790204
ankyrin 3, epithelial
IDBP-790206
ankyrin 3, epithelial
IDBP-790208
ankyrin 3, epithelial
IDBP-790210
ankyrin 3, epithelial
IDBP-790211
ankyrin 3, epithelial
IDBP-790212
ankyrin 3, epithelial
IDBP-790213
ankyrin 3, epithelial
IDBP-790214
ankyrin 3, epithelial
IDBP-790215
ankyrin 3, epithelial
IDBP-790216
ankyrin 3, epithelial
IDBP-790218
ankyrin 3, epithelial
IDBP-790219
ankyrin 3, epithelial
IDBP-790220
ankyrin 3, epithelial
IDBP-790221
ankyrin 3, epithelial
IDBP-790222
ankyrin 3, epithelial
IDBP-790223
ankyrin 3, epithelial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:69533772-70027438
Strand Forward strand
Band B5.3
Transcripts
ENSMUST00000092434 ENSMUSP00000090090
ENSMUST00000092431 ENSMUSP00000090087
ENSMUST00000047061 ENSMUSP00000045834
ENSMUST00000092432 ENSMUSP00000090088
ENSMUST00000054167 ENSMUSP00000061698
ENSMUST00000092433 ENSMUSP00000090089
ENSMUST00000182379
ENSMUST00000182194
ENSMUST00000182884 ENSMUSP00000138326
ENSMUST00000182373
ENSMUST00000182155 ENSMUSP00000138347
ENSMUST00000183169 ENSMUSP00000138348
ENSMUST00000183148 ENSMUSP00000138770
ENSMUST00000182557 ENSMUSP00000138603
ENSMUST00000182439 ENSMUSP00000138356
ENSMUST00000182142
ENSMUST00000182992 ENSMUSP00000138686
ENSMUST00000182474
ENSMUST00000182162
ENSMUST00000182492
ENSMUST00000182993 ENSMUSP00000138601
ENSMUST00000183240 ENSMUSP00000138474
ENSMUST00000182972 ENSMUSP00000138481
ENSMUST00000182683 ENSMUSP00000138375
ENSMUST00000182239
ENSMUST00000182367
ENSMUST00000182692 ENSMUSP00000138623
ENSMUST00000182269 ENSMUSP00000138123
ENSMUST00000183261 ENSMUSP00000138095
ENSMUST00000183074 ENSMUSP00000138671
ENSMUST00000182029 ENSMUSP00000138337
ENSMUST00000182687
ENSMUST00000181974 ENSMUSP00000138285
ENSMUST00000182795 ENSMUSP00000138413
ENSMUST00000182437 ENSMUSP00000138586
ENSMUST00000182762
ENSMUST00000186247 ENSMUSP00000139496
ENSMUST00000183082 ENSMUSP00000138092
ENSMUST00000182207 ENSMUSP00000138531
ENSMUST00000182606
ENSMUST00000183023 ENSMUSP00000138450
ENSMUST00000182665 ENSMUSP00000140773
ENSMUST00000185582 ENSMUSP00000140724
ENSMUST00000183001
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0007009 plasma membrane organization
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007528 neuromuscular junction development
GO:0010650 positive regulation of cell communication by electrical coupling
GO:0019228 neuronal action potential
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0043001 Golgi to plasma membrane protein transport
GO:0045184 establishment of protein localization
GO:0045760 positive regulation of action potential
GO:0050808 synapse organization
GO:0071709 membrane assembly
GO:0072659 protein localization to plasma membrane
GO:0072660 maintenance of protein location in plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005764 lysosome
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0009925 basal plasma membrane
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0030424 axon
GO:0030425 dendrite
GO:0031594 neuromuscular junction
GO:0033268 node of Ranvier
GO:0033270 paranode region of axon
GO:0042383 sarcolemma
GO:0043005 neuron projection
GO:0043194 axon initial segment
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000151150
View Gene Order
ENSBTAG00000019052
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_22266
Interaction between L1 and Ankyrins pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt G5E8K5
TrEMBL G3X971 G5E8K2 G5E8K3 Q3UVY0 Q8CCD5 Q99N60 Q9WUD7 S4R165 S4R187 S4R1S2 S4R1U4 S4R1X7 S4R208 S4R229 S4R236 S4R278 S4R2C1 S4R2F5 S4R2J6 S4R2K9 S4R2S8 W4VSQ0
UniProt Splice Variant
Entrez Gene 11735
UniGene Mm.235960 Mm.382431 Mm.410029 Mm.413448 Mm.471958
RefSeq NM_009670 NM_146005 NM_170687 NM_170688 NM_170689 NM_170690 NM_170728 NM_170729 NM_170730 XM_006513122 XM_006513123 XM_006513124 XM_006513125 XM_006513126 XM_006513127 XM_006513128 XM_006513129 XM_006513130 XM_006513131 XM_006513132 XM_006513133
OMIM
CCDS CCDS23909 CCDS23910 CCDS23911 CCDS23912 CCDS35931 CCDS48590 CCDS59545 CCDS59546
HPRD
IMGT
MGI ID MGI:88026
MGI Symbol Ank3
EMBL AB057357 AC100427 AC129018 AC132435 AC156836 AF130364 AK033389 AK035681 AK136830 AK162007 BC021657 CH466553 L40631 L40632 U89274 U89275
GenPept AAB01602 AAB01603 AAB01607 AAB58380 AAB58381 AAD29415 AAH21657 BAB39357 BAC28262 BAC29151 BAE23139 BAE36677 EDL31984 EDL31985 EDL31986 EDL31989 EDL31990 EDL31991 EDL31994
RNA Seq Atlas 11735

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca