InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sh3gl2

Summary

InnateDB Protein

IDBP-160705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sh3gl2

Protein Name

SH3-domain GRB2-like 2

Synonyms

9530001L19Rik; AI120490; AW555077; B930049H17Rik; EEN-B1; Sh3d2a; SH3PA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030212

InnateDB Gene

IDBG-160703 (Sh3gl2)

Protein Structure

UniProt Annotation

Function

Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. {ECO:0000269PubMed:10490020}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Concentrated in presynaptic nerve terminals in neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 64 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	64 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0042802	identical protein binding

Biological Process

GO:0002090	regulation of receptor internalization
GO:0048488	synaptic vesicle endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:700009

InterPro

IPR001452 SH3 domain
IPR004148 BAR domain
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
IPR018859 BAR domain-containing family

PFAM

PF00018
PF14604
PF03114
PF07653
PF10455

PRINTS

PR00452
PR01887

PIRSF

SMART

SM00326
SM00721

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt