Version 5.4
Mus musculus Protein: Upk1b
Summary
InnateDB Protein IDBP-160733.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Upk1b
Protein Name uroplakin 1B
Synonyms AI413235; Tspan20; UPIb; Upk1;
Species Mus musculus
Ensembl Protein ENSMUSP00000052469
InnateDB Gene IDBG-160731 (Upk1b)
Protein Structure
UniProt Annotation
Function Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Bladder epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:98912
InterPro IPR008952 Tetraspanin, EC2 domain
IPR018499 Tetraspanin/Peripherin
PFAM PF00335
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z2C6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 22268
UniGene Mm.490676
RefSeq NP_849255
MGI ID
MGI Symbol Upk1b
OMIM
CCDS CCDS28174
HPRD
IMGT
EMBL AF073956 AF274865 AK053004 AK083101 AK086926 BC046604
GenPept AAD02834 AAH46604 AAM97593 BAC35237 BAC38760 BAC39763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca