InnateDB Protein
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IDBP-160829.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dad1
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Protein Name
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defender against cell death 1
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Synonyms
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AI323713;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022781
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InnateDB Gene
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IDBG-160827 (Dad1)
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Protein Structure
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Function |
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER) (By similarity). Loss of the DAD1 protein triggers apoptosis. {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
Accession |
GO Term |
GO:0004576
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oligosaccharyl transferase activity
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GO:0004579
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dolichyl-diphosphooligosaccharide-protein glycotransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:101912
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InterPro |
IPR003038
DAD/Ost2
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PFAM |
PF02109
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PRINTS |
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PIRSF |
PIRSF005588
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61804
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PhosphoSite |
PhosphoSite-P61804
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
13135
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UniGene |
Mm.319038
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RefSeq |
NP_001106829
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MGI ID |
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MGI Symbol |
Dad1
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OMIM |
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CCDS |
CCDS27084
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HPRD |
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IMGT |
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EMBL |
AF051310
AK002446
AK006711
AK030925
AK054480
BC024378
BC053379
BC058116
U22107
U81050
U81051
U83628
U84209
U84210
Y13335
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GenPept |
AAA85855
AAB58539
AAC05296
AAC53098
AAC53359
AAH24378
AAH53379
AAH58116
BAB22107
BAB24711
BAC35796
BAE20464
CAA73779
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